Recent advances in biological applications of mannich bases — An overview

Mannich bases are beta-amino ketone-carrying compounds that the end products of reaction. The reaction is essential in synthesis nitrogen-containing compounds. reaction, a nucleophilic addition forms carbon-carbon bonds, employed numerous natural products, drugs and other There several aminoalkyl chain bearing with high curative value, such as fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, many others. According to literature, highly reactive have been demonstrated powerful anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral, antilipase activity properties. primary source of, -α,β-unsaturated ketone, which can be produced by deaminating hydrogen atom amine group, responsible for biological action bases. However, number minor functions reported, including their ability control blood pressure or prevent platelet aggregation, impact on parasites ulcers, use medications mental health issues. Since there greater need anticonvulsant pharmaceuticals, these containing N-mannich base groups will exhibit an increase lipophilic nature hence improved blood-brain barrier penetration. overview concludes brief explanation potential inhibitors various enzymes ligands receptors.